Original Article
Expression and bioinformatic analysis of C1QBP in non-small cell lung cancer
Wei Li, Yonghong Zhang, Xuan Liu, Hongni Zhang, Wenjing Deng, Yujie Zhong, Li Ma, Na Zhang, Shuanying Yang
Published 2019-05-05
Cite as Int J Respir, 2019, 39(9): 656-662. DOI: 10.3760/cma.j.issn.1673-436X.2019.09.003
Abstract
ObjectiveIt has been proven that complement component 1q subcomponent binding protein (C1QBP) might play an important role in the oncogenesis and progression of numerous malignant tumors.The aim of this study is to evaluate the relationship between C1QBP and non-small cell lung cancer.
MethodsThe expression of C1QBP was detected by immunohistochemical method in 46 cases of non-small cell lung cancer and 24 cases of normal lung tissue in the Second Affiliated Hospital of Xi′an Jiaotong University.TNM stage, lymph node metastasis, cell differentiation and expression of C1QBP were evaluated.The bioinformatic of C1QBP were analyzed.
ResultsThe expression of C1QBP was significantly higher in NSCLC tissues than that in normal lung tissues (P<0.05). The strength of positive expression was not correlated with the gender, age, TNM stages, lymph node metastasis and histological type, and was correlated with the degree of tumor differentiation.Bioinformatic analysis suggested that C1QBP was mainly located in the mitochondria and has MAM33 domain.C1QBP plays a certain role in signal transduction, stress response and immune response.The KNG1 protein screened by the STRING database interacts with C1QBP.
ConclusionsC1QBP may play an important role in the oncogenesis of NSCLC.C1QBP may be a novel biomarker for the diagnosis of NSCLC and a new target for its treatment.
Key words:
Lung Neoplasms; Immunohistochemistry; Computational Biology; Complement component 1q subcomponent-binding protein
Contributor Information
Wei Li
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Yonghong Zhang
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Xuan Liu
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Hongni Zhang
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Wenjing Deng
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Yujie Zhong
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Li Ma
Department of Pathology, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Na Zhang
Department of Pathology, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
Shuanying Yang
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
