To observe the effects of transnasal high-flow oxygen therapy on the patients with type Ⅱ acute respiratory failure.

80 patients with type Ⅱ acute respiratory failure admitted to the Affiliated Huaihai Hospital of Xuzhou Medical University from July 2017 to December 2019 were selected as the research subjects.According to the random number table method, all patients were divided into study group (given transnasal high-flow oxygen therapy) and control group (given non-invasive positive pressure ventilation therapy), 40 cases in each group.The treatment effect, oxygen saturation (SpO₂), arterial partial pressure of oxygen (PaO₂), arterial partial pressure of carbon dioxide (PaCO₂), oxygenation index, heart rate (HR), mean arterial pressure (MAP), respiratory frequency (RR) and oxidative stress indicators before treatment and after treatment for 2, 12, 24, 48 hours were analyzed.The end-point events/comorbidities after treatment in the two groups were observed.

After treatment for 2, 12, 24, 48 hours, the effect of the study group was significantly better than that of the control group (all P<0.05). Before treatment, there was no significant difference in SpO₂, PaO₂, PaCO₂ and oxygenation index between the two groups.After treatment for 2, 12, 24, 48 hours, SpO₂, PaO₂ and oxygenation index of the study group were all higher than those of the control group (all P<0.05), and PaCO₂ of the study group was lower than that of the control group (all P<0.05). Before treatment, there was no significant difference in HR, MAP and RR between the two groups.After treatment for 2, 12, 24, 48 hours, HR, MAP and RR of the study group were lower than those of the control group (allP<0.05). Before treatment, there was no significant difference in malondialdehyde (MDA) and superoxide dismutase (SOD) between the two groups.After treatment for 2, 12, 24, 48 hours, MDA of the study group was lower than that of the control group (allP<0.05), and SOD of the study group was higher than that of the control group (allP<0.05). After treatment, the reintubation rate and the incidence of diarrhea in the study group were lower than those in the control group, but there was no significant difference between the two groups.The incidence of delirium, stay time after extubation in intensive care unit, and total stay time in intensive care unit in the study group were lower than those in the control group (allP<0.05).

Both transnasal high-flow oxygen therapy and non-invasive positive pressure ventilation can treat patients with type Ⅱ acute respiratory failure, but the effect of transnasal high-flow oxygen therapy is quite good, which is worthy of clinical application.

Transnasal high-flow oxygen therapy; Noninvasive positive pressure ventilation; Acute respiratory failure; Respiratory rate; Partial pressure of carbon dioxide