Original Article
Risk factors and consequences for concurrent obesity hypoventilation syndrome in patients with obstructive sleep apnea
Yan Yuxia, Zhang Jing, Wang Yan, Chen Baoyuan, Cao Jie
Published 2021-12-05
Cite as Int J Respir, 2021, 41(23): 1790-1794. DOI: 10.3760/cma.j.cn131368-20201218-01155
Abstract
ObjectiveTo investigate the clinical characteristics and risks of obstructive sleep apnea (OSA) complicated with obesity hypopnea syndrome (OHS).
MethodsA retrospective analysis was made in 179 OSA patients diagnozed in the Sleep Center of Tianjin Medical University General Hospital from March 2019 to May 2020.According to combined with OHS, the patients were divided into OSA group (n=147), OSA combined with OHS group (n=32). OHS group was subdivided into morbid obesity group with 11 cases and non-morbid obesity group with 21 cases.The clinical characteristics of OSA group and OSA combined with OHS group, morbid obesity group and non-morbid obesity group were compared.The risk factors of OSA combined with OHS were analyzed by binary logistic regression.
ResultsWaist circumference, smoking rate, apnea hypopnea index (AHI), oxygen desaturation index(ODI), arousal index, and percentage of total sleep time with oxygen saturation below 90% (SIT90) were higher in combined OHS group than in OSA group, respectively (126.68±18.66 vs 115.54±13.76) cm, AHI (74.13±32.40 vs 57.33±30.60) times/h, ODI (73.70±33.40 vs 73.70±33.40) times/h, and arousal index (51.15±31.64 vs 33.69±21.66) times/h, SIT90 (44.59±30.95 vs 19.75±21.80)% (P<0.05). The average SpO2 and lowest SpO2 at night, forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) were lower than OSA group, respectively FEV1 (2.51±0.94 vs 3.00±0.90) L, FVC (3.23±0.99 vs 3.73±1.01) L, (P<0.05). The neck circumference, waist circumference and ODI of morbid obesity group were higher than those of non-morbid obesity group, the average SpO2 at night was lower than that of non-morbid obesity group (all P<0.05). Multivariate logistic regression showed waistline, BMI, AHI, and SIT90 independent risk factors for OSA and OHS.
ConclusionsPatients with OSA complicated with OHS have worse sleep quality and more obvious night hypoxia.
Key words:
Sleep apnea, obstructive; Obesity hypoventilation syndrome; Polysomnography; Risk factors
Contributor Information
Yan Yuxia
Department of Respiratory, Tianjin Medical University General Hospital 300052, China
Yan Yuxia is now at the Department of Respiratory and Critical Care Medicine, Yichun People′s Hospital, Yichun 336099, China
Zhang Jing
Department of Respiratory, Tianjin Medical University General Hospital 300052, China
Wang Yan
Department of Respiratory, Tianjin Medical University General Hospital 300052, China
Chen Baoyuan
Department of Respiratory, Tianjin Medical University General Hospital 300052, China
Cao Jie
Department of Respiratory, Tianjin Medical University General Hospital 300052, China
