Original Article
Systematic evaluation and meta-analysis of chronic obstructive pulmonary disease and occupational exposure
Zhu Jun, Yang Ting, Wang Chen
Published 2022-01-20
Cite as Int J Respir, 2022, 42(2): 118-125. DOI: 10.3760/cma.j.cn131368-20210926-00721
Abstract
ObjectiveTo investigate the association between occupational exposure, single or combined exposure to vapors, gases, dusts or fumes (VGDF), and chronic obstructive pulmonary disease (COPD).
MethodsLiteratures on the relationship between occupational exposure and COPD were comprehensively searched in PubMed, Cochrane Library, Wanfang, CNKI and other databases since the establishment of the databases until the end of April of 2020.Meta-analyses were performed using fixed or random effects models to assess the overall effect and 95% confidence interval (95%CI). Newcastle-Ottawa Scale was used to evaluate the methodological quality of the included literatures.
ResultsA total of 759 literatures were identified from the initial search.Of these, 652 studies were on the secondary shortlist after removing the duplicates.According to the inclusion criteria, 637 were excluded after perusing the title, abstract and full-text.Finally, 15 studies with 38 271 subjects were included in this meta-analysis.The OR values (95%CI) of total exposure, high exposure and low exposure to VGDF were 1.32 (1.04-1.67), 1.54 (1.22-1.94), and 1.22 (1.01-1.47), respectively.OR (95%CI) for high and low combined gas/smoke exposures were 1.25 (1.05-1.48), and 1.08 (0.99-1.19), respectively.The OR values (95%CI) of high exposure low exposure to gases, dusts/fumes were 1.25 (1.05-1.48), and 1.08 (0.99-1.19), respectively.The OR values (95%CI) of the overall exposure, high exposure and low exposure to biological dust summary were 1.57 (1.01-2.43), 1.31 (0.99-1.73), and 1.10 (0.99-1.21), respectively.The OR values (95%CI) of the overall exposure, high exposure and low exposure to mineral dust were 1.23 (0.83-1.82), 1.20 (1.01-1.43), and 1.10 (0.99-1.23), respectively.
ConclusionsExposures to VGDF, high exposure to gases/fumes, overall biological dust exposure and high exposure to mineral dust are associated with increased risk of COPD.Occupational exposure protection should be strengthened to prevent the occurrence and progression of COPD.
Key words:
Pulmonary disease, chronic obstructive; Occupational exposure; Vapors; Gases; Dusts; Fumes
Contributor Information
Zhu Jun
Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing 101149, China
Yang Ting
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Institute of Respiratory Medicine, Chinese Academy of Medical Science, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China
Wang Chen
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Institute of Respiratory Medicine, Chinese Academy of Medical Science, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China
