Review
Relationship between chronic obstructive pulmonary disease and airway microbiota
Wang Rong, Shi Guochao, Zhang Yunhui
Published 2022-01-20
Cite as Int J Respir, 2022, 42(2): 144-150. DOI: 10.3760/cma.j.cn131368-20210824-00618
Abstract
Chronic obstructive pulmonary disease (COPD) has become one of the global disease burdens with high morbidity and high mortality.In addition to traditional bronchodilators, glucocorticoids, antibiotics and other therapeutic measures, new prevention and treatment measures and therapeutic targets need to be developed urgently.In recent years, with the development of gene sequencing technology, more progress has been made in the study of COPD airway microbiota.This article will review the characteristics of the airway microbiota of COPD and its correlation with COPD, the mechanism of airway microbiota affecting the occurrence and development of COPD, the effects of smoking and glucocorticoids on COPD airway microbiota, and the application of microbial-related therapies in the treatment of COPD, so as to provide new ideas of microbial-based targeted therapy for the prevention and treatment of COPD.
Key words:
Pulmonary disease, chronic obstructive; Smoking; Corticosteroids; Airway microbiota; Immune response
Contributor Information
Wang Rong
Medical School, Kunming University of Science and Technology, Kunming 650000, China
Shi Guochao
Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China
Zhang Yunhui
Department of Pulmonary and Critical Care Medicine, the Affiliated Hospital of Kunming University of Science and Technology, the First People′s Hospital of Yunnan Province, Kunming 650000, China
