Original Article
Short-term efficacy and safety of low dose rivaroxaban for acute pulmonary thromboembolism
Zhang Anbing, Yuan Xiaoling, Xia Xiuqiong, Lyu Yanhua, Zhang Dandan, Liang Jianping
Published 2022-02-20
Cite as Int J Respir, 2022, 42(4): 275-278. DOI: 10.3760/cma.j.cn131368-20210923-00709
Abstract
ObjectiveTo investigate the short-term efficacy and safety of low dose rivaroxaban for patients with acute pulmonary embolism.
MethodsA total of 112 patients with acute pulmonary embolism were randomly divided into experimental group and control group.The control group was given rivaroxaban 15 mg twice a day, changed to 20 mg once a day after three weeks; the experimental group was given rivaroxaban 10 mg twice a day, and changed to 15 mg once a day after three weeks.The course of treatment was three months.The short-term efficacy, incidence of bleeding, length of stay and medical expenses of the two groups were compared.
ResultsThe short-term efficacy of the two groups was similar (P>0.05); the incidence of bleeding in the experimental group was significantly lower than that in the control group (χ2=4.15, P<0.05). The average length of stay, outpatient and hospitalization expenses in the experimental group were significantly lower than those in the control group (t=2.53, 3.88, 2.46, all P<0.05).
ConclusionsCompared with conventional dose, low dose of rivaroxaban for treating patients with acute pulmonary embolism has the same effect, lower incidence of bleeding, shorter hospital stay, and lower outpatient and hospitalization expenses, which implies low dose is worthy of clinical application.
Key words:
Acute pulmonary thromboembolism; Rivaroxaban; Low dose; Curative effect; Safety
Contributor Information
Zhang Anbing
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
Yuan Xiaoling
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
Xia Xiuqiong
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
Lyu Yanhua
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
Zhang Dandan
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
Liang Jianping
Department of Respiratory and Critical Care Medicine, Zhongshan People′s Hospital, Zhongshan 528400, China
