Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) syndrome is a rare disease with unknown and debated etiology, characterized by rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation.Recently, Russian scholars reported a case of COVID-19-associated ROHHAD-like syndrome.Neuroendocrine tumors can be associated in more than half of the cases.This rare condition has a severe outcome because of high morbidity and mortality.In this article provides a comprehensive description of the etiopathogenetic theories of the disease, clinical presentation, diagnostic workup and treatment possibilities.