Original Article
Effects and associated factors of HIV/AIDS anti-retroviral therapy in Liangshan Yi Autonomous Prefecture, Sichuan Province
Jiali Xu, Chunnong Jike, Ye Ma, Gang Yu, Ju Wang, Ke Wang, Peng Xu, Qiang Liao, Yuhan Gong, Shiyong Zhong, Hu Liu, Ersha Jike, Lin Pang, Zhongfu Liu
Published 2018-06-06
Cite as Chin J Prev Med, 2018, 52(6): 668-672. DOI: 10.3760/cma.j.issn.0253-9624.2018.06.018
Abstract
ObjectiveTo evaluate the effectiveness and to explore the releated factors of antiretroviral therapy among HIV/AIDS patients in Liangshan Yi Autonomous Prefecture, Sichuan Province.
MethodsThe method of convenience sampling was adopted in July 2017 to select the research objects who were accepted antiretroviral therapy (ART) over 6 months, older than 18 years and had HIV viral load in 2016, totally 400 cases. A retrospective study was used to collect the data, including social demography, medicine use, information of medical service acquisition, their own behaviors and cognition. 395 questionnaires were effectively recovered. χ2 test and logistic regression were performed to examine relationships between factors and effects.
ResultsAll of the 395 respondents were Yi-nationality. The average age of all cases was (39.23±7.52) years old and 223 were male (56.5%). Among 395 cases patients who were detect Viral load in 2016, 221 cases were under the number of 400 copies, thze effective rate of ART was 55.9%. Multivariate analysis showed that HIV/AIDS patients who missed the medication during the antiviral therapy had poor antiviral effects. Compared to those who adhered to medication, the treatment-ineffective OR (95%CI) of the patients missing the medication during the therapy was 7.06 (3.67-13.58); Compared to those who had adverse reactions that affect the therapy, the treatment-ineffective OR (95%CI) of the patients with mild adverse reactions that did not affect the therapy was 0.45 (0.23-0.87); Compared to the patients who used drugs during the treatment, the treatment-ineffective OR (95%CI) value of the antiretroviral therapy effect of non-drug users was 0.39 (0.16-0.91);Compared to the patients who have a correct cognition that insisting on taking medicine correctly can extend their life expectancy as a common person, the treatment-ineffective OR (95%CI) values for those who hold the view that could be prolonged by 10-20 years and not/unknown were 4.18 (1.59-10.99) and 6.64 (2.67-16.53).
ConclusionThe HIV/AIDS patients who receive ART were less effective in Liangshan, Prefecture. Missings drugs is one of the main influencing factors for the ineffective treatment.
Key words:
AIDS; Anti-retroviral therapy; Treatment effect; Cross-section studies; Risk factors
Contributor Information
Jiali Xu
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Chunnong Jike
Ye Ma
Gang Yu
Ju Wang
Ke Wang
Peng Xu
Qiang Liao
Yuhan Gong
Shiyong Zhong
Hu Liu
Ersha Jike
Lin Pang
Zhongfu Liu
