Original Article
Retrospective clinical analyses of otogenic intracranial infections
Liang Chai, Jing Hu, Yongjun Mao, Quancheng Li, Zhili Zhang
Published 2018-10-07
Cite as Chin J Otorhinolaryngol Head Neck Surg, 2018, 53(10): 770-775. DOI: 10.3760/cma.j.issn.1673-0860.2018.10.010
Abstract
ObjectiveTo investigate the clinical characteristics and treatment options for otogenic intracranial infections.
MethodClinical records of all the patients of otogenic intracranial infections admitted to the First Affiliated Hospital of Zhejiang University from 2008 to 2016 were retrospectively analyzed. Their clinical presentations, radiological findings, culture results, and medical and surgical therapy modalities, as well as treatment outcomes were studied.
ResultsSixteen cases were identified. The majority of the otogenic patients had a history of cholesteatoma, other rare events included congenital cerebrospinal fluid otorhinorrhea, Gorham-Stout disease and after radiation therapy for nasopharyngeal carcinoma. Meningitis, cerebral venous thrombosis and brain abscess were the primary intracranial infection. Eight patients had received modified radical mastoidectomy at least one time. Results of routine culture for cerebrospinal and pus samples had high negative rate. All patients received initial empirical broadspectrum intravenous antibiotics therapy. Four cases of brain abscesses were drained or excised at the same time for otologic surgery. The mortality rate was 6.25% (1 case).
ConclusionsCholesteatoma is still the most commonly primary disease of otogenic intracranial complications. Diagnosis and treatment of otogenic intracranial infections require multidisciplinary cooperation. Surgical intervention for primary ear lesions and intracranial abscess is still the main option in the treatment of otogenic intracranial infections.
Key words:
Otitis media; Cholesteatoma; Brain abscess
Contributor Information
Liang Chai
Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Jing Hu
Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Yongjun Mao
Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Quancheng Li
Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Zhili Zhang
Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
