Original Article
Inquiry on clinical application value of NLR and PLR in chronic obstructive pulmonary disease
Hongjun Wang, Dawen Ma, Feng Liu, Yan Tan
Published 2019-06-05
Cite as Int J Respir, 2019, 39(11): 834-840. DOI: 10.3760/cma.j.issn.1673-436X.2019.11.007
Abstract
ObjectiveTo explore the clinical value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) in chronic obstructive pulmonary disease (COPD), and compared with C-reactive protein (CRP).
MethodsIn this study, the clinical data of 157 patients with clear diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were enrolled, and their stable period (SCOPD) data were collected.The clinical data, which were collected from 146 patients of health examination in Pukou Branch, Jiangsu Province Hospital, were randomly taken as the reference group.To explore the value of NLR and PLR in predicting the risk of acute exacerbation of COPD and investigate the correlation between the NLR, PLR and the lung function of COPD patients.
Results(1)Compared with the healthy control group and the SCOPD group, the NLR (H=164.205, P<0.05), PLR (H=82.467, P<0.05), and CRP (H=181.571, P<0.05) in the AECOPD group were significantly increased.ROC curve analysis showed that CRP sensitivity was 83.2%, specificity was 78.5%.NLR sensitivity was 68.3%, specificity was 80.5%.PLR sensitivity was 60.5%, and specificity was 71.0%.(2)There was no significant difference in NLR (H=2.708, P>0.05), PLR (H=5.614, P>0.05) and CRP (H=3.909, P>0.05) index among patients with Ⅰ-Ⅳ COPD.
ConclusionsNLR, PLR and CRP levels have high diagnostic value for AECOPD, and NLR and CRP have similar diagnostic accuracy.There is no significant correlation between lung function severity in patients with NLR, PLR, and COPD.
Key words:
Pulmonary disease, chronic obstructive; C-reactive protein; Neutrophil-lymphocyte count ratio; Platelet to lymphocyte ratio
Contributor Information
Hongjun Wang
Department of Pulmonary and Critical Care Medicine, Pukou Branch, Jiangsu Province Hospital, Nanjing 211800, China
Dawen Ma
Department of Pulmonary and Critical Care Medicine, Pukou Branch, Jiangsu Province Hospital, Nanjing 211800, China
Feng Liu
Department of Pulmonary and Critical Care Medicine, Pukou Branch, Jiangsu Province Hospital, Nanjing 211800, China
Yan Tan
Department of Pulmonary and Critical Care Medicine, the First Hospital of Nanjing, Nanjing 210006, China
