Review
Application value of NT-ProBNP and BNP in children with congenital heart disease
Xiaolong Zhang, Xiaoyun Wu
Published 2019-10-26
Cite as Int J Pediatr, 2019, 46(10): 713-717. DOI: 10.3760/cma.j.issn.1673-4408.2019.10.004
Abstract
Congenital heart disease(CHD)is the most common congenital malformation and also one of the common causes of heart failure in children.At present, the clinical diagnosis of heart failure in children mainly depends on the medical history, symptoms and signs, with strong subjectivity and lack of timely and simple objective criteria, which are easy to be missed.Brain natriuretic peptide(BNP) and N-terminal pro-brain natriuretic peptide(NT-ProBNP) are polypeptides synthesized and secreted by ventricular myocytes, which have good sensitivity to reflect ventricular systolic, diastolic function and pre- and post-load.They have been widely used in various cardiovascular diseases.In recent years, many studies have shown that the plasma concentration of the two can be used to guide perioperative surgical treatment and evaluate the perioperative prognosis risk of children with CHD.This article reviews the application of BNP and NT-ProBNP in children with CHD with heart failure, especially during perioperative period.
Key words:
Brain natriuretic peptide; N-terminal pro-brain natriuretic peptide; Congenital heart disease; Heart failure; Perioperative period
Contributor Information
Xiaolong Zhang
Department of Cardiology, Children′s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014 China
Xiaoyun Wu
Department of Cardiology, Children′s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014 China