Lumbar disc herniation is one of the most common orthopaedic diseases. With the increasingly improvement of the diagnosis and treatment strategies of lumbar disc herniation, it is necessary to standardize the diagnosis and treatment procedures in lumbar disc herniation. Based on the principle of evidence-based medicine, the guideline was developed according to the Expert Consensus and Clinical Pathway of Diagnosis and Treatment Guidelines for Lumbar Disc Herniation developed by Special Scientific Research Project of Medical Industry in 2013 and clinical guidelines of diagnosis and treatment of lumbar disc herniation with radiculopathy developed by North America Spine Society in 2013. After guideline registration, plan publication, expert working group development, clinical problem screening and determination, the authors systematically reviewed literatures from the data base of China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Biology Medicine and PubMed. According to inclusion and exclusion criteria, the guideline included 119 literatures with 109 in English and 10 in Chinese. Grading of Recommendations Assessment Development and Evaluation System was used to rate the quality of evidence and determined the strength of recommendations. Recommendations were derived from quality of evidence body. After three rounds of discussions in expert work group, clinical guidelines for diagnosis and treatment of lumbar disc herniation were finally developed. The guidelines defined the screening for definition, natural history, symptoms and signs, auxiliary examination, diagnostic criteria, conservative treatment, surgical treatment, evaluation of surgical effect and influencing factors of surgical effect. It can provide a reliable clinical basis for the diagnosis and treatment in lumbar disc herniation and can improve the prognosis of patients with lumbar disc herniation.