Based on large sample of clinical epidemiology survey, we discussed the etiology and pathogenesis of type-2 diabetes. On the basis of Internal Classic of Huang Di, and discussions of both ancient and modern doctors, we believed that: type 2 diabetes is just like Jueyin disease of Treatise on Febrile Disease, characterizing by adverse-rising of Qi, cold mingling with heat and deficiency mingling with access. The diseased location is spleen, and closely related with liver and lung. The pathogenesis is the failure transportation and transformation of spleen, floating of deficient five visceral essence, and turbid dampness flowing down to form yin fire syndrome. The reason for failure transportation and transformation of spleen includes depression of lung, adverse flow of liver-qi, dampness accumulation in the middle and deficiency of kidney Qi.

Diabetes mellitus, type 2; Etiology and pathogenesis; Five evolutive phases and six climatic factors; Body constitution; Jueyin disease