To explore the clinical features of Sweet′s syndrome and analyze its histopathological features and treatment.

The general data, clinical manifestations, laboratory examination, histopathological examination and treatment of 36 patients with Sweet′s syndrome who admitted our hospital from 2013 to 2019 were retrospectively analyzed.

The male to female ratio is 1∶1, with the highest incidence in the 50-60 years old range (27.8%). Skin lesions were more common in head and neck (30.6%), limbs (27.8%), upper limbs (19.4%) and whole body (22.2%). Accompanying symptoms were observed in 20 patients (55.6%) and most common are fever (47.2%) and joint pain (19.4%). Malignant tumors were associated with 5 patients (13.9%), chronic inflammation or infection with 17 patients (47.2%), diabetes mellitus with 4 patients (11.1%) and pregnancy with 3 patients (8.3%). It is most easily misdiagnosed as erythema polyforms (11.1%) and allergic dermatitis dermatitis (11.1%). Histopathologic features ware dermal papillary edema, dermal neutrophilic infiltration and nuclear dust. All patients relieved after glucocorticoid therapy.

The proportion of male and female in Sweet syndrome is close to the same. Chronic infection and malignant tumor are the most common causes, which are easy to be misdiagnosed in clinic. Comprehensive evaluation of patients′ systemic diseases and accurate histopathological analysis are helpful for early identification and diagnosis of Sweet syndrome.

Sweet syndrome; Signs and symptoms; Pathological conditions