Review
Research progress of thyroid hormone synthesis related genes and iodine metabolism and thyroid diseases
Nie Guanying, Li Ming, Sun Dianjun
Published 2020-08-20
Cite as Chin J Endemiol, 2020, 39(8): 619-624. DOI: 10.3760/cma.j.cn231583-20200312-00038
Abstract
Iodine is an important raw material for thyroid hormone synthesis. Sodium iodide symporter (NIS), chloride iodine transporter (Pendrin), iodotyrosine deiodinase (IYD), thyroglobulin (TG), thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) are important genes related to thyroid hormone synthesis, all of them are involved in iodine metabolism. The dysfunction of genes related to thyroid hormone synthesis is not only related to thyroid diseases, but also related to other diseases such as breast cancer. In this paper, the function of genes related to thyroid hormone synthesis, the relationship between genes related to thyroid hormone synthesis and diseases, and how to be regulated by iodine are reviewed, in order to provide new ideas for the study of the relationship between iodine and diseases.
Key words:
Iodine; Thyroid hormones; Sodium iodide symporter; Chloride iodine transporter; Iodotyrosine deiodinase; Thyroglobulin; Thyroid peroxidase; Thyroid stimulating hormone receptor
Contributor Information
Nie Guanying
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Li Ming
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Sun Dianjun
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
