Clinical Research
Association of oxidative stress markers and MRI overall burden with vascular cognitive impairment in patients with ischemic cerebral small-vessel diseases
Wang Ya'nan, Yao Lin, Mao Wenjing, Liu Xing, Li Shiying, Liu Bin
Published 2020-10-20
Cite as Chin J Behav Med & Brain Sci, 2020, 29(10): 898-903. DOI: 10.3760/cma.j.cn371468-20191202-00868
Abstract
ObjectiveTo explore the correlation between oxidative stress markers malondialdehyde(MDA), superoxide dismutase(SOD), magnetic resonance burden and vascular cognitive impairment in patients with ischemic cerebrovascular disease (CSVD).
MethodsTotally 300 patients with ischemic cerebral small vessel diseases who were admitted to the Department of Neurology, North China University of Science and Technology Affiliated Hospital were selected as the research subjects, and 60 healthy outpatients in the same period were selected as the control group.According to the results of mini mental state examination(MMSE), patients with ischemic cerebral small vessel diseases were divided into cognitive normal group (106 cases) and cognitive impairment group (194 cases). The cognitive impairment group was further divided into mild cognitive impairment group (101 cases), moderate cognitive impairment group (58 cases ) and severe cognitive impairment group (35 cases) according to Montreal cognitive assessment (MoCA). MDA and SOD were determined by double antibody sandwich method and the results were compared and analyzed.
Results(1) Compared with the control group(MDA: (8.40±1.81)μmol/L, SOD: (112.73±83.48)U/ml), the level of MDA increased while the level of SOD decreased significantly in normal group(MDA: (8.46±2.05)μmol/L, SOD: (108.90±88.72)U/ml) and cognitive impairment group(MDA: (12.19±7.02)μmol/L, SOD: (62.64±20.34)U/ml). Compared with the cognitive normal group, the level of SOD decreased significantly and MDA increased significantly in cognitive impairment group, the differences were statistically significant (allP<0.05). Compared with the normal cognitive group (1.18±1.10), the cognitive impairment group (1.93±1.05) had a higher MRI burden score (P<0.05). (2)Multivariate analysis showed that the decrease of plasma SOD level(β=-0.024, OR=0.977, 95%CI=0.961-0.992)and the increase of plasma MDA level(β=0.110, OR=1.117, 95%CI=1.005-1.241)and the MRI overall burden(β=0.453, OR=1.573, 95%CI=1.011-2.446)were independent protective factors of vascular cognitive impairment in patients with ischemic CSVD.(3) Compared with mild cognitive impairment group(MDA: (9.79±5.79)μmol/L, SOD: (81.64±58.09)U/ml, MRI overall burdern (1.69±0.99)), the level of SOD decreased significantly and the level of MDA and the MRI overall burden increased significantly in moderate cognitive impairment group and severe cognitive impairment group(MDA: (7.95±2.44)μmol/L, SOD: (76.13±46.00)U/ml, MRI overall burden: (1.78±0.86)), (MDA: (11.16±6.68)μmol/L, SOD: (63.49±20.04)U/ml, MRI overall burden: (2.89±1.02). Compared with the moderate cognitive impairment group, the level of SOD decreased significantly and the level of MDA and the MRI overall burden increased significantly in the severe cognitive impairment group (allP<0.05).
ConclusionIncreased plasma MDA level, MRI burden score and decreased SOD level in patients with CSVD are all risk factors for the occurrence of cognitive impairment.It is suggested that oxidative stress injury and cerebral small vessel lesions may be involved in the occurrence and development of cognitive impairment of CSVD from multiple aspects.
Key words:
Gerebral small vessel disease; Vascular cognitive impairment; Oxidative stress markers; Malondialdehyde; Superoxide dismutase; MRI overall burden
Contributor Information
Wang Ya'nan
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
Yao Lin
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
Mao Wenjing
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
Liu Xing
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
Li Shiying
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
Liu Bin
First Department of Neurology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
