Dental caries is a chronic infectious disease that occurs in the tooth hard tissues. Increasing evidence has also indicated a close involvement of dental caries in the onset and development of systemic diseases. In recent years along with the advances in high throughput-omics technologies, disease animal models, multicenter clinical studies, as well as the research and development in novel dental materials, digital and minimal invasive clinical techniques, robust progress have been made in the field of etiology, pathogenesis, diagnosis, prevention and treatment of dental caries. More importantly, the strategy of whole life cycle management of caries has promoted the combinatory management of dental caries and other systemic chronic diseases, and it has also shed light on the age-based management and risk-control-oriented personalized treatment of caries. In the future, more efforts should be warranted to further the basic research and accelerate its clinical application, so as to advance the early diagnosis, comprehensive prevention and functional-aesthetic treatment with minimal invasive intervention of carious teeth, and ultimately to promote the population-based whole lifecycle management of caries.

Dental caries; Dental caries susceptibility; Diagnosis; Caries prevention; Minimal invasive treatment of caries