Review
Prevalence status and microbiological characteristics of community-associated methicillin-resistant Staphylococcus aureus infection
Gu Lei, Lai Guoxiang, Lin Dengshu, Yu Zongyang, Ye Jia, Liu Wei
Published 2021-02-05
Cite as Int J Respir, 2021, 41(3): 207-211. DOI: 10.3760/cma.j.cn131368-20200511-00384
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the common nosocomial pathogens and can also cause community-related infections.Community-associated MRSA (CA-MRSA) and hospital-associated MRSA (HA-MRSA) are different in many aspects.CA-MRSA strains are mainly staphylococcal chromosome mec gene cassette Ⅳ or type Ⅴ, and are sensitive to most non-β lactam antibacterial drugs.Most of them carry Panton-Valentine leukocidin.CA-MRSA is more toxic than HA-MRSA, not only due to Panton-Valentine leukocidin, toxins encoded by core genomes such as α-toxin and phenol-soluble modulin-α are also important reasons for its high toxicity and high pathogenicity.The mecA gene is a resistance gene that causes Staphylococcus aureus to be resistant to β-lactam antibiotics, while resistance to non-β-lactam antibiotics depends on whether it carries other resistance genes.This paper reviews the epidemiology, virulence factors and drug resistance genes of CA-MRSA, and the difference between CA-MRSA and HA-MRSA.
Key words:
Community-associated; Methicillin-resistant Staphylococcus aureus; Virulence factors; Resistance gene
Contributor Information
Gu Lei
Department of Respiratory Medicine, Fuzhou General Hospital of Fujian Medical University, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Fuzhou 350025, China
Lai Guoxiang
Department of Respiratory Medicine, Fuzhou General Hospital of Fujian Medical University, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Fuzhou 350025, China
Lin Dengshu
Ningde Medical District, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Ningde 352000, China
Yu Zongyang
Department of Respiratory Medicine, Fuzhou General Hospital of Fujian Medical University, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Fuzhou 350025, China
Ye Jia
Department of Respiratory Medicine, Fuzhou General Hospital of Fujian Medical University, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Fuzhou 350025, China
Liu Wei
Department of Respiratory Medicine, Fuzhou General Hospital of Fujian Medical University, the 900th Hospital of the Joint Logistic Support Force, People′s Liberation Army of China, Fuzhou 350025, China
