Zheng Zhi, Ding Yixuan, Mei Wentong, Guo Yulin, Qu Yuanxu, Lu Jiongdi, Liu Shuang, Sun Haichen, Cao Feng, Li Fei
Abstract
Malignant tumors usually have no obvious clinical symptoms in the early stage. Most patients are already in the advanced stage when they are diagnosed. Some patients have lost the opportunity for operation, resulting in poor prognosis. Therefore, how to find the best therapeutic target for such patients and improve the prognosis of patients has gradually become the focus of scholar′s attention. Recently, Kruppel-like factor (KLF) is a transcriptional regulator that can bind to the target DNA, and its family plays an important role in the occurrence and development of malignant tumors. It has also been confirmed that the KLF family affects the proliferation, differentiation and migration of tumor cells, but the specific mechanism is still not fully elucidate. Consequently, in order to further explored the effect of the KLF family on tumors, this study intends to briefly review the roles and regulatory mechanisms of the KLF family in the cell proliferation, differentiation and migration of malignant tumors, hoping to provide new target for the biological treatment of tumors.
Key words:
Neoplasms; Transcription factors; Kruppel-like factor; Malignant tumor; Regulatory mechanism
Contributor Information
Zheng Zhi
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Ding Yixuan
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Mei Wentong
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Guo Yulin
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Qu Yuanxu
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Lu Jiongdi
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Liu Shuang
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Sun Haichen
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Cao Feng
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
Li Fei
Department of General Surgery, Xuan Wu Hospital, Capital Medical University
Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, China
