Review
Research progress on high-mobility group box 1 protein-Toll-like receptor 4/receptor for advanced glycation end products signaling pathway in acute lung injury/acute respiratory distress syndrome
Bi Le, Fan Shaohui, Xu Yu, Shu Xiaoyi, Wang Hongman
Published 2021-05-05
Cite as Int J Respir, 2021, 41(9): 703-708. DOI: 10.3760/cma.j.cn131368-20200420-00316
Abstract
Acute lung iniury (ALI)/acute respiratory distress syndrome (ARDS) is an acute respiratory insufficiency caused by diffuse interstitial and alveolar edema.High-mobility group box 1 protein (HMGB1), as an important late inflammatory factor in the inflammatory progression of ALI/ARDS, can bind to cell surface receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation end products (RAGE), activate the downstream pathway, and then induce the transcription of various inflammatory factors.HMGB1-TLR4/RAGE signaling pathway is complex, and the mechanism of action in the ALI/ARDS process is unclear.This paper reviews the research progress of HMGB1-TLR4/RAGE signaling pathway in ALI/ARDS in order to find new therapeutic targets for ALI/ARDS.
Key words:
Acute lung iniury; Respiratory distress syndrome, adult; High-mobility group box 1 protein; Toll-like receptor 4; Receptor for advanced glycation end products; Inflammatory factor
Contributor Information
Bi Le
Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
Fan Shaohui
Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
Xu Yu
Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
Shu Xiaoyi
Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
Wang Hongman
Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
