Clinical Research
A summary of the best evidence for the prevention of oral mucositis associated with radiotherapy and chemotherapy in children with hematological tumors
Li Lianye, Wang Chunli, Wu Xinyi, Chen Fangjiao, Liang Rui, Gu Ying
Published 2021-05-26
Cite as Chin J Mod Nurs, 2021, 27(15): 1992-1997. DOI: 10.3760/cma.j.cn115682-20200815-04911
Abstract
ObjectiveTo retrieve, evaluate and integrate domestic and foreign relevant evidence on the prevention of oral mucositis related to chemoradiotherapy in children, and summarize the best evidence, so as to provide clinical practice guidelines for medical staff.
MethodsWe systematically searched the evidence on the prevention of oral mucositis related to chemoradiotherapy in children in British Medical Journal (BMJ) Best Practice, UpToDate, Joanna Briggs Institute (JBI) Evidence-based Health Care Center Database, National Guideline Clearinghouse, Registered Nurses' Association of Ontario, Scottish Intercollegiate Guidelines Network, United Kingdom National Institute for Health and Care Excellence, International Practice Guideline Registry Platform (Chinese) , Multinational Association of Supportive Care in Cancer, International Society of Oral Oncology, European Society for Medical Oncology, American Society of Clinical Oncology, Cochrane Library, BMJ Journals, PubMed, Embase, China National Knowledge Infrastructure (CNKI) , WanFang Data and China Biology Medicine Database. The evidence included clinical practice guidelines, expert consensus, best practices, systematic reviews and evidence summaries, and the search time limit was to build the database until November 1, 2019. The searched guidelines were independently evaluated by four guideline reviewers, and the rest of literature was independently evaluated by two researchers who received evidence-based training to evaluate the quality of the included literature, combined with the judgment of professionals. Evidence extraction and evidence summary were carried out on literature that met the quality standards.
ResultsA total of 8 articles were included, including 1 BMJ best practice, 5 JBI evidence summaries, 1 guideline, and 1 systematic review. The best evidence included 16 pieces of evidence in 7 areas of basic oral care, nursing evaluation, diet prevention, physical therapy, drug prevention, fungal infection prevention, and multidisciplinary team management.
ConclusionsThis study summarizes the best evidence for the prevention of oral mucositis related to chemoradiotherapy in children, and provides clinical practice guidelines for medical staff. Medical institutions should establish preventive measures for children's oral mucositis related to chemoradiotherapy based on the transformation of evidence-based evidence, and establish standardized multidisciplinary collaboration and nursing procedures to improve patient health outcomes.
Key words:
Child; Hematologic neoplasms; Oral mucositis; Best practice; Radiotherapy; Chemotherapy
Contributor Information
Li Lianye
Intensive Care Unit, National Center for Children's Health (Beijing) , Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Wang Chunli
Nursing Department, National Center for Children's Health (Beijing) , Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Wu Xinyi
Nursing Department, National Center for Children's Health (Beijing) , Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Chen Fangjiao
Hematologic Neoplasms Center, National Center for Children's Health (Beijing) , Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Liang Rui
Hematologic Neoplasms Center, National Center for Children's Health (Beijing) , Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Gu Ying
Nursing Department, National Center for Children's Health (Shanghai) , Children's Hospital of Fudan University, Shanghai 201102, China
