Review
Activation mechanism of immune cells by vaccine adjuvant
Cao Luqian, Wang Huan, Ling Hong, Li Yan
Published 2021-05-05
Cite as Int J Immunol, 2021, 44(3): 335-339. DOI: 10.3760/cma.j.issn.1673-4394.2021.03.018
Abstract
Prophylactic vaccines are the most effective means for control the epidemic of infectious diseases.Vaccine adjuvants can enhance the immunogenicity of vaccine antigen and increase the titer of specific antibody.Adjuvants can enhance the ability of antigen presenting cells(APCs) to take and present antigens by interacting with different kinds of Toll like receptors(TLRs), NOD like receptors(NLRs) or cyclic-GMP-AMP synthase(cGAS). However, different kinds of adjuvants may induce a certain bias of CD4+ T cell differentiation into different subtypes due to the activation of different types of pattern recognition receptors(PRR). This review summarized the role and mechanism of adjuvant in activating immune cells to provide reference for the selection and application of vaccine adjuvants.
Key words:
Vaccine; Adjuvant; Antigen presenting cells; Immune enhancement
Contributor Information
Cao Luqian
Department of Microbiology, Harbin Medical University, Key Laboratory of Infection and Immunity of Heilongjiang Province, Key Laboratory of Pathogenic Biology of Heilongjiang Province, Harbin 150081, China
Wang Huan
Department of Microbiology, Harbin Medical University, Key Laboratory of Infection and Immunity of Heilongjiang Province, Key Laboratory of Pathogenic Biology of Heilongjiang Province, Harbin 150081, China
Ling Hong
Department of Microbiology, Harbin Medical University, Key Laboratory of Infection and Immunity of Heilongjiang Province, Key Laboratory of Pathogenic Biology of Heilongjiang Province, Harbin 150081, China
Li Yan
Department of Microbiology, Harbin Medical University, Key Laboratory of Infection and Immunity of Heilongjiang Province, Key Laboratory of Pathogenic Biology of Heilongjiang Province, Harbin 150081, China
