Clinical Research
Characteristics of resting-state brain voxel-mirrored homotopic connectivity in patients with chronic schizophrenia
Yang Weiliang, Cheng Yongying, Li Yan, Xu Shuli, Zhuo Chuanjun, Li Jie
Published 2021-06-20
Cite as Chin J Behav Med & Brain Sci, 2021, 30(6): 510-514. DOI: 10.3760/cma.j.cn371468-20210122-00034
Abstract
ObjectiveTo investigate the brain characteristics of chronic schizophrenia by voxel-mirrored homotopic connectivity (VMHC).
MethodsForty seven patients with chronic schizophrenia from Tianjin Anding Hospital and 31 healthy controls from nearby communities were included in the study. The MRI data of the subjects were collected by Siemens Skyra 3.0 T MRI.Positive and negative symptoms scale (PANSS) was used to assess the illness severity of patients with chronic schizophrenia.SPM12 was used to process the collected MRI data. DPARSF was used to calculate the VMHC values of subjects in the two groups. The independent sample t test based on SPM12 was used to compare the VMHC values of the two groups. The significant brain regions in VMHC were regarded as regions of interest (ROI), and VBM8 was used to further analyze the gray matter volume of the ROI of the two groups.
ResultsCompared with healthy controls, the patients with chronic schizophrenia demonstrated decreased VMHC mainly located in lingual gyrus(voxel=208, T=4.98), occipital middle occipital gyrus(voxel=156, T=3.75) and postcentral gyrus(voxel=237, T=4.36) (FDR correction, q=0.05). Compared with healthy controls, the gray matter volumes in bilateral lingual gyrus(left(0.0034±0.0008), (0.0028±0.0013), t=-2.141, P=0.037; right(0.0025±0.0006), (0.0020±0.0011), t=2.268, P=0.028) and postcentral gyrus((0.0432±0.0051), (0.0372±0.0162), t=-2.070, P=0.045) increased, but non-significant change in postcentral gyrus of the patients with chronic schizophrenia.
ConclusionThe abnormal VMHC mainly locate in lingual gyrus, middle occipital gyrus and postcentral gyrus in patients with chronic schizophrenia.
Key words:
Chronic schizophrenia; Functional magnetic resonance imaging; Voxel-mirrored homotopic connectivity; Gray matter volume
Contributor Information
Yang Weiliang
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
Cheng Yongying
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
Li Yan
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
Xu Shuli
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
Zhuo Chuanjun
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
Li Jie
Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China
Tianjin Anding Hospital, Tianjin 300202, China
