Review
The research progress of the mechanism and treatment for radiation-induced cognitive dysfunction
Wang Mengmeng, Zhou Yingqi, Han Yi, Cheng Ying
Published 2021-07-08
Cite as Chin J Neurol, 2021, 54(7): 718-722. DOI: 10.3760/cma.j.cn113694-20201018-00792
Abstract
Radiotherapy is still a major part of the program about treating various head and neck cancers. While improving the survival rate of head and neck cancer patients, radiotherapy can cause the decline of learning, memory, orientation and other functions, seriously, even lead to dementia, namely radiation induced cognitive dysfunction (RICD), which has become a critical factor affecting the quality of life for patients. Because of occult onset and unclear pathogenesis, so far there is few effective preventive and therapeutic tools for RICD. In this paper, the latest research progress on the pathogenesis and treatments of RICD is summarized.
Key words:
Cognition disorders; Radiotherapy; Oxidative stress; Inflammation
Contributor Information
Wang Mengmeng
Department of Hyperbaric Oxygen and Neurology, Naval Special Medical Center Chinese People′s Liberation Army, Shanghai 200052, China
Zhou Yingqi
Department of Hyperbaric Oxygen and Neurology, Naval Special Medical Center Chinese People′s Liberation Army, Shanghai 200052, China
Han Yi
Department of Hyperbaric Oxygen and Neurology, Naval Special Medical Center Chinese People′s Liberation Army, Shanghai 200052, China
Cheng Ying
Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University of Chinese People′s Liberation Army, Shanghai 200433, China