To evaluate the characteristics of diastolic left intraventricular pressure differences(IVPD) and intraventricular pressure gradients(IVPG) among normal adults in different ages by vector flow mapping.

From March 2019 to October 2020, 1 093 healthy volunteers were selected from the physical examination center of the Second Affiliated Hospital of Harbin Medical University, and they were divided into youth group (18-40 years old), middle-aged group (41-65 years old) and elderly group (>65 years old). IVPD and IVPG during isovolumetric relaxation(IR) period, rapid filling (RF) period, slow filling(SF) period, and atrial contraction(AC) period were measured by vector flow mapping, and were correlated with left ventricular diastolic function parameters.

①IVPD-IR, IVPD-AC, IVPG-IR, and IVPG-AC gradually increased while IVPD-RF, IVPD-SF, and IVPG-RF gradually decreased from the youth group to the elderly group(all P<0.05). ②IVPD-RF and IVPG-RF were positively correlated with E(r=0.391, 0.402, P<0.001, respectively). IVPD-AC and IVPG-AC were positively correlated with A(r=0.407, 0.425, P<0.001, respectively) and E/e′(r=0.268, 0.294, P<0.001, respectively) while negatively correlated with E/A(r=-0.510, -0.506, P<0.001, respectively) and e′/a′(r=-0.514, -0.511, P<0.001, respectively).

IVPD and IVPG can quantitatively analyze the changes of left ventricular hemodynamics in normal subjects, which are expected to be new indexes to evaluate left ventricular diastolic function.

Vector flow mapping; Relative pressure imaging; Left intraventricular pressure differences; Normal adults; Left ventricular diastolic function