Cutaneous squamous cell carcinoma (cSCC) is one of the most common non-melanoma skin cancers. In recent years, with the in-depth study of its pathogenesis, as well as the development of diagnostic technology, Mohs micrographic surgery, targeted therapy and immunotherapy, great progress has been made in the diagnosis and treatment of cSCC. Based on recent domestic and international relevant literature and guidelines, and combined with the availability of diagnostic and therapeutic methods in China, this consensus focuses on clinical manifestations, classification, biopsy pathology and report standards, risk factor assessment, grading, staging, and standardized treatment of cSCC, and aims to provide a reference for the diagnosis and treatment of cSCC in clinical practice.