To investigate the relationship between mycoplasma pneumoniae (MP) - immunoglobulin G (IgG)/IgM and total IgG/IgM in patients with MP infection.

A total of 101 patients with mycoplasma pneumonia in Foshan Traditional Chinese Medicine Hospital from September to December 2020 were selected as an observation group (57 males and 44 females, aged from 16 to 83 years), and 96 healthy people during the same period were selected as a control group (51 males and 45 females, aged from 18 to 79 years). The levels of serum MP-IgG/IgM in the two groups were detected by chemiluminescence method, and the levels of serum total IgG/IgM in the two groups were detected by immunoturbidimetric method. The correlations between the changes of MP-IgG/IgM and the serum total IgG/IgM were discussed in patients with MP infection.

MP-IgG and MP-IgM were 123.5 (34.8, 278.5) Au/ml and 1.22 (0.72, 2.57) COI in the observation group, and those were 5.55 (3.75, 7.73) Au/ml and 0.24 (0.13, 0.42) COI in the control group, with statistically significant differences between the two groups (both P<0.05). There was no statistically significant difference in the total IgM between the observation group and the control group (P>0.05), there was a statistically significant difference in the total IgG between the two groups (P<0.05), but the distribution values of the two groups were within the normal reference range. There was no convergent relationship between MP-IgG/IgM and total IgG/IgM in the observation group.

The levels of MP-IgG /IgM in serum of patients with MP infection increase dynamically. The increase of MP-IgG/IgM levels can be used as a diagnostic basis for recent or previous infection of MP. However, the levels of total IgG/IgM do not show a trend correlation with the changes of MP-IgG/IgM. The levels of serum total IgG/IgM are not suitable for the diagnosis of MP infection.

MP-IgG; MP-IgM; Total IgG; Total IgM; Mycoplasma pneumoniae infection