Due to the factors such as poor efficacy of traditional chemotherapy against drug-resistant tuberculosis strains, long treatment time and serious side effects, it is urgent for new treatment methods to improve this situation. Host-directed therapy(HDT) is a new type of anti-infection therapy. As a new method of tuberculosis treatment, it can enhance the efficacy of chemical drugs, shorten the treatment time, enhance antibacterial immunity, and improve immune pathological damage. In this article, several HDT pathways and the mechanisms are summarized, which provide a reference for finding new and effective anti-tuberculosis therapy.