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Analysis of clinical features of 16 cases with Chlamydia psittaci pneumonia
Fang Changquan, Xu Limin, Lu Jiancong, Xie Yanjun, Tan Hongyi, Lin Junhong
Published 2021-11-28
Cite as Chin Crit Care Med, 2021, 33(11): 1366-1369. DOI: 10.3760/cma.j.cn121430-20210810-01159
Abstract
ObjectiveTo analyze the clinical characteristics of Chlamydia psittaci pneumonia and to investigate the correlation between serum inflammatory biomarkers and severity of the disease.
MethodsSixteen patients with Chlamydia psittaci pneumonia admitted to the Huizhou Municipal Central Hospital from January 2020 to July 2021 were selected as the study subjects, including 10 severe cases and 6 mild cases. Clinical data were collected and analyzed, such as baseline characteristics, clinical symptoms, laboratory inspection and chest imaging manifestations.
Results① Thirteen Chlamydia psittaci pneumonia were associated with a definite bird or poultry contact history. Common symptoms included high fever, chill, cough, fatigue, and anorexia (16 cases), dyspnoea (12 cases), and other systemic symptoms. ② Laboratory test results showed normal white blood cell count (WBC, 10 cases), decreased lymphocyte count (LYM, 13 cases), increased high sensitive C-reactive protein (hs-CRP, 16 cases), D-dimer (15 cases), lactate dehydrogenase (LDH, 13 cases), aspartate aminotransferase (AST, 16 cases) and alanine aminotransferase (ALT, 12 cases) levels, however, the albumin (Alb, 15 cases) lever was decreased. The numbers of CD3+ T cells and CD4+ T cells decreased in 10 patients. ③ The levels of D-dimer, interleukins (IL-2, IL-6, IL-10) in severe Chlamydia psittaci pneumonia were significantly higher than those in mild Chlamydia psittaci pneumonia [D-dimer (μg/L): 10 257±4 203 vs. 1 085±642, IL-2 (ng/L): 1.1 (0.8, 1.7) vs. 0.3 (0.1, 0.7), IL-6 (ng/L): 315 (182, 505) vs. 75 (18, 131), IL-10 (ng/L): 7.0±4.1 vs. 2.3±0.7], but the LYM was lower (×109/L: 0.4±0.1 vs. 1.1±0.4), with significant differences (all P < 0.05). ④ Chest imaging manifestations were exudative lesions and large consolidation of lungs. Large consolidation of both lungs can occur in some critically ill patients.
ConclusionsChlamydia psittaci pneumonia is mainly associated with a bird or poultry contact history. The clinical manifestations usually present high fever, dyspnea, normal or slightly increased leucocytes, and lung consolidation. The levels of LYM, D-dimer, IL-2, IL-6 and IL-10 in serum are expected to predict the severity of the Chlamydia psittaci pneumonia.
Key words:
Chlamydia psittaci; Pneumonia; Inflammatory cytokine; Clinical feature
Contributor Information
Fang Changquan
Department of Respiratory and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, China
Xu Limin
Department of Geriatrics, Huizhou First People's Hospital, Huizhou 516000, Guangdong, China
Lu Jiancong
Department of Respiratory and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, China
Xie Yanjun
Department of Respiratory and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, China
Tan Hongyi
Department of Respiratory and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, China
Lin Junhong
Department of Respiratory and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, China
