Original Article
Effects of 0.02% and 0.01% Atropine on Astigmatism in Myopic Children
Wang Ming, Fu Aicun, Cui Can, Yu Shiao, Jiao Zhantao, Ye Gang, Ma Jingxue
Published 2022-02-25
Cite as Chin J Optom Ophthalmol Vis Sci, 2022, 24(2): 123-130. DOI: 10.3760/cma.j.cn115909-20210817-00325
Abstract
Objective:To evaluate the effects of 0.02% and 0.01% atropine eye drops on total astigmatism and corneal astigmatism in myopic children.
Methods:A prospective cohort study. The cohort study assessed 400 myopic children between June 2016 and June 2017 and divided them into three groups: 138 and 142 children were randomized to use either 0.02% or 0.01% atropine eye drops, respectively. They wore single-vision spectacles (SVS), with one drop of atropine applied to both eyes once nightly. The children in the control group (n=120) only wore SVS. Spherical equivalent refractive (SE) and corneal curvature were measured every 4 months for 1 year. SE and corneal curvature were assessed by cycloplegic autorefraction and IOLMaster. Total and corneal astigmatism were calculated by standardized vector analysis and then split into its power vector components: X, Y and axes. Only the right eye was selected for data analysis. An analysis of variance test, rank sum test and Chi-square test were used for data analysis. Repeated measures analysis of variance and the generalized estimation equation GEE model were used to compare the changes in total astigmatism, corneal astigmatism and the axial changes in corneal astigmatism.
Results:After 1 year, there was a small but significant increase in total astigmatism (including X), which had statistically significant differences in the 0.02% and 0.01% atropine and control groups (total astigmatism: Ftime=15.25, P=0.001; total astigmatism X: χ2time=48.07, P<0.001). Total astigmatism (including X) changed at the same rate in the 3 groups, and there were nostatistically significant differences among the groups. There was a small but significant increase in corneal astigmatism (including X), which was significantly different over time in the three groups (corneal astigmatism:Ftime=8.11,P=0.001; corneal astigmatism X: χ2time=20.79, P<0.001). Total astigmatism (including X) changed at the same rate in the 3 groups, and there was no statistically significant difference among the groups. There were no significant changes in the total and corneal astigmatism Y and their axes in the three groups over 1 year and the changes were not significantly different.
Conclusion:Children with myopia who regularly instilled 0.02% or 0.01% atropine eye drops for 1 year showed no effect on total astigmatism, corneal astigmatism, or their axes after standardized vector analysis.
Key words:
low concentration atropine; myopia; children; astigmatism
Contributor Information
Wang Ming
Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Fu Aicun
Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Cui Can
Department of Ophthalmology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Yu Shiao
Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Jiao Zhantao
Department of Emergency, Hebei General Hospital, Shijiazhuang 050000, China
Ye Gang
Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Ma Jingxue
Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
