Serum prenatal screening in the second trimester is currently the prenatal screening method with the highest population coverage rate, and large-scale serum prenatal screening has become a trend. The Medical Genetics Committee of the Chinese Eugenics Science Association organized some experts in prenatal screening in China to jointly draft the " Expert Consensus on the Scientific Management of Serum Prenatal Screening" , which focusing on the organization and management of large-scale serum prenatal screening and quality control in the laboratory, for reference by domestic counterparts.