Jaundi ce can occur in most neonates. Most jaundice is benign, but beacuse of the potent ial toxicity of bilirubin, newborn infants with severe hyperbilirubinemi a can develop acute bilirubin encephalopathy or kernicterus. InOctober 2004, American academic of pediatrics produced the latest guideline for newborn jaundi ce aim to reduce the incidence of acute bilirubin encephalopathy or kernicterus and avoid unnecessary costs or treatment. The latest guideline emphasizes the important of successful breastfeeding, time of jaundice developed, assessment for the risk of severe hyperbilirubinemia, close follow-up, and prompt intervention when indi cated, provide a framework for the prevention and management of hyperbilirubinemia in newborn infants of 35 or more weeks of gestation. Some new view in the latest guideline may be helpful to us.