To explore the clinical curative effects and safety of mirabilite and borneol for external application treatment of drug-induced phlebitis.

Literatures related to the treatment of drug-induced phlebitis by external application of mirabilite and borneol were searched by computer from CNKI, Wanfang, VIP, Pubmed, Cochrane Library, Embase and other Chinese and English databases. The retrieval period was from the establishment of the databases to October 23, 2021. STATA 15.0 software was used for statistical analysis of data.

A total of studies with 767 patients (384 in the treatment group and 383 in the control group) were included. Meta-analysis results showed that the cure rate of mirabilite and borneol in the treatment of phlebitis (RR=1.84, 95%CI: 1.40-2.42, P<0.05) , the total effective rate (RR=1.12, 95%CI: 1.02-1.24, P<0.05) and pain score (SMD=3.34, 95%CI: -5.20- -1.48, P<0.01) were better than those in the control group.

External application of mirabilite and borneol is more suitable for the clinical treatment of drug-induced phlebitis than magnesium sulfate and other external treatment preparations, showing advantages in clinical performance (cure rate and total effective rate) and safety (adverse events) . However, due to the small sample size of some indicators, the quantitative results obtained should be carefully applied to clinical practice and further research is needed to support this conclusion.

Phlebitis; External application of mirabilite and borneol; Meta-analysis