Liver Cancer
Predictive value of prognostic inflammatory and tumor score in intrahepatic cholangiocarcinoma
Ma Bingqi, Meng Huijuan, Dong Xiaofeng, Gao Xuelei, Wu Yuning, Zhang Wei, Li Shiping, Shen An
Published 2022-07-20
Cite as Chin J Hepatol, 2022, 30(7): 777-783. DOI: 10.3760/cma.j.cn501113-20211108-00539
Abstract
ObjectiveTo compare and analyze the predictive value of different inflammatory factors and tumor markers in intrahepatic cholangiocarcinoma and to develop a new and effective preoperative prognostic scoring system.
Methods102 and 72 cases with intrahepatic cholangiocarcinoma who underwent radical surgery in Tianjin Medical University Cancer Institute and Hospital and the Affiliated Hospital of Weifang Medical University were selected as the experimental group and the validation group, respectively. Clinicopathological and follow-up data were collected. Cox proportional-hazards model was used to analyze the predictive value of different prognostic markers. The relationship between prognostic markers and clinicopathological data was analyzed by rank sum test, χ2 or Fisher's exact test.
ResultsAmong the direct inflammatory factors, tumor markers and combined inflammatory factors, prognostic inflammatory index (PII), carbohydrate antigen (CA) 19-9 and systemic inflammation score (SIS) were the most significant predictive factors for postoperative survival outcomes in patients with intrahepatic cholangiocarcinoma. The prognostic inflammatory and tumor score (PITS) was proposed as a new prognostic scoring system for intrahepatic cholangiocarcinoma. PII and CA19-9 were included into the scoring criteria for prognostic stratification of patients. PITS was an independent predictor of tumor-free survival and overall survival in patients with intrahepatic cholangiocarcinoma. Patients with high-grade PITS had later tumor grade and higher frequency of vascular invasion.
ConclusionPITS is highly effective prognostic scoring system for patients with intrahepatic cholangiocarcinoma. In addition, PITS is recommended for preoperative prognostic stratification in patients with intrahepatic cholangiocarcinoma.
Key words:
Intrahepatic cholangiocarcinoma; Prognostic inflammatory and tumor score; Prognosis; Inflammatory factor; Tumor marker
Contributor Information
Ma Bingqi
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Meng Huijuan
Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Dong Xiaofeng
Department of Hepatobiliary, Pancreas and Spleen Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region (Guangxi Academy of Medical Sciences), Nanning 530021, China
Gao Xuelei
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Wu Yuning
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Zhang Wei
Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
Li Shiping
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Shen An
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
