Original Article
Value of serum pepsinogen Ⅰ, Ⅱ and gastrin-17 in screening precancerous lesions of gastric cancer in physical examination population
Ye Ting, Ding Yifeng, Jin Tingting, Jin Haifeng, Lyu Bin, Shen Liyan
Published 2022-09-05
Cite as Chin J Postgrad Med, 2022, 45(9): 782-786. DOI: 10.3760/cma.j.cn115455-20210824-01080
Abstract
ObjectiveTo evaluate the value of serum pepsinogen Ⅰ and Ⅱ combined with gastrin-17 in screening precancerous lesions of gastric cancer in physical examination population.
MethodsSerum pepsinogen, gastrin-17 and Helicobacter pylori (Hp) antibody were detected in 18 354 physical examination people from July to December 2017 in Wenrong Hospital, Hengdian, Dongyang. The patients were divided into youth group (18 to 39 years old), middle-aged group (40 to 59 years old) and elderly group (≥60 years old) according to their ages. The correlation between the serological level of the above indexes and age was analyzed; according to the new ABC method, the test results were divided into groups A, B, C and D. The patients in group C and D were examined by gastroscopy. The differences of gastric mucosal atrophy or intestinal metaplasia and other precancerous lesions detected by gastroscopy in different age groups were compared.
ResultsFinally, 18 354 cases were enrolled, including 9 614 males and 8 740 females. With the increase of age, the proportion of group C and D increased gradually. In group C, 181 cases underwent gastroscopy, including 39 cases of atrophic gastritis, 29 cases of intestinal metaplasia and 3 cases of dysplasia/intraepithelial neoplasia, the detection rate of precancerous lesions was 39.23%; in group D, 94 cases underwent gastroscopy, including 22 cases of atrophic gastritis and 13 cases of intestinal metaplasia, the detection rate of precancerous lesions was 37.23%. The proportion of gastric precancerous lesions in group C and D was 29.63% in the young group, 69.70% in the middle-aged group and 71.58% in the old group, respectively. There was significant difference compared with the young group (P<0.01); atypical hyperplasia occurred in 2.02% and 9.47% of the middle-aged group and the elderly group.
ConclusionsThe combined detection of serum pepsinogen Ⅰ and Ⅱ and gastrin-17 levels is of great value in the screening of precancerous lesions of gastric cancer; when this method used for early gastric cancer screening in healthy population, it is necessary to consider the influence of age for the risk stratification of gastric cancer.
Key words:
Serology; Pepsinogens; Gastrin-17; Precancerous lesions of gastric cancer; Gastric cancer screening
Contributor Information
Ye Ting
Endoscopy Center, Wenrong Hospital, Hengdian, Dongyang 322100, China
Ding Yifeng
Endoscopy Center, Wenrong Hospital, Hengdian, Dongyang 322100, China
Jin Tingting
Endoscopy Center, Wenrong Hospital, Hengdian, Dongyang 322100, China
Jin Haifeng
Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
Lyu Bin
Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
Shen Liyan
Endoscopy Center, Wenrong Hospital, Hengdian, Dongyang 322100, China
