To search, evaluate and summarize the best evidence for non-pharmaceutical therapy of cancer-related fatigue in cancer patients.

According to the "6S" evidence model, systematically searched relevant domestic and foreign guideline networks and databases to collect relevant evidences, including clinical decision support, guidelines, evidence summaries, and systematic reviews. Retrieval time from the establishment of the database to August 2021. After evaluating the quality of the literature, we extracted and summarized relevant evidence.

A total of 18 articles were included in this study, including 1 clinical decision support, 4 clinical practice guidelines, 5 evidence summarie and 8 systematic reviews. 25 pieces of best evidence were summarized, involving non-pharmacological interventions in 7 aspects: health education, exercise intervention, psychosocial intervention, traditional Chinese medicine therapy, nutritional support, sleep therapy and bright white light therapy.

It is recommended that medical staff should combine clinical practice, scientifically select the best evidence and use evidence-based management scheme for cancer-related fatigue to reduce cancer-related fatigue and improve patients′ life quality.

Neoplasms; Cancer-related fatigue; Non-pharmacological interventions; Evidence summary; Evidence-based nursing