Review
Correlation between type 2 diabetes mellitus and primary open angle glaucoma
Liu Jinlong, Hu Haijian, Zhang Xu
Published 2022-10-22
Cite as Int Rev Ophthalmol, 2022, 46(5): 471-477. DOI: 10.3760/cma.j.issn.1673-5803.2022.05.016
Abstract
Glaucoma and diabetic eye disease are both serious vision-threatening diseases worldwide. Patients with type 2 diabetes mellitus (T2DM) may be accompanied by optic nerve degeneration and retinal ganglion cells(RGC) apoptosis, which are similar to the optic nerve damage of primary open-angle glaucoma (POAG). Risk factors such as high intraocular pressure, vasculopathy and retinal thinning in patients with T2DM may aggravate the progression of POAG, while pharmacological treatments for diabetes such as metforminmay have a protective effect on POAG. Further exploration of the relationship between T2DM and POAG may help reduce the risk of visual impairment in patients with T2DM and discover new treatment target for POAG.(Int Rev Ophthalmol, 2022, 46: 471-477)
Key words:
primary open angle glaucoma; type 2 diabetes mellitus; optic nerve; blood flow regulation
Contributor Information
Liu Jinlong
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China
Hu Haijian
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China
Zhang Xu
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China
