Clinical Research
Effects of esketamine on remifentanil dosage and postoperative pain in obese patients undergoing general anesthesia
Liu Xiangjie, Lin Huafu, Cheng Fang, Li Richang, Zhang Xiaodan, Li Weijian
Published 2023-01-15
Cite as IMHGN, 2023, 29(2): 265-268. DOI: 10.3760/cma.j.issn.1007-1245.2023.02.028
Abstract
ObjectiveTo evaluate the effects of esketamine on remifentanil dosage and postoperative pain in obese patients undergoing general anesthesia.
MethodsSixty obese patients taking selective non-chest surgery at Jiangmen Central Hospital from June 2020 to May 2021 were selected for the clinical control trial; they were 18-65 years old; their body mass index (BMI) was over 28 kg/m2; the anesthesia grade was Ⅱ-Ⅲ. The patients were divided into an experimental group and a control group, with 30 cases in each group. The experimental group used esticketamine, propofol, sufentanil, and cisatracurium for anesthesia induction. The control group used sufentanil and cisatracurium at the same doses and a different dose of propofol for anesthesia induction. The experimental group took esticketamine, sevoflurane, and remifentanil for anesthesia maintenance. The control group took propofol, sevoflurane, and remifentanil for anesthesia maintenance. In both groups, the doses of sevoflurane, propofol, and esticketamine were constant, and the doses of remifentanil were adjusted according to intraoperative hemodynamic changes. Other drugs and fluids were consistent. Postoperative analgesia were induced by intravenous pump with flurbiprofen axetil in both groups. The amounts of remifentanil and postoperative Visual Analogue Scale (VAS) pain scores of both groups were recorded. The data were compared between these two groups by independent-sample t test and χ2 test.
ResultsThe VAS scores 2, 6, 12, and 24 h after operation in the experimental group were lower than those in the control group [(2.37±0.50) vs. (2.85±1.13), (3.05±0.46) vs. (3.45±0.42), (3.30±0.47) vs. (3.70±1.19), and (3.40±0.64) vs. (3.90±0.90)], with statistical differences (P<0.05). The amount of remifentanil in the experimental group was less than that in the control group [(1 130.00±109.92) μg vs. (1 210.00±108.12) μg], with a statistical difference (t=2.842, P=0.006).
ConclusionEsketamine can reduce remifentanil dosage and postoperative pain score in obese patients undergoing general anesthesia.
Key words:
General anesthesia; Esketamine; Remifentanil; Visual Analogue Scale
Contributor Information
Liu Xiangjie
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
Lin Huafu
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
Cheng Fang
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
Li Richang
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
Zhang Xiaodan
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
Li Weijian
Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen 529000, China
