Clinical Research
The correlation between white blood cell count, neutrophil-lymphocyte ratio and depression severity in patients with first episode depression
Jin Man, Liang Hao, Ni Aihua, Zhang Shipan, Fei Di, Lyu Peiyuan
Published 2023-01-20
Cite as Chin J Behav Med & Brain Sci, 2023, 32(1): 45-49. DOI: 10.3760/cma.j.cn371468-20220815-00467
Abstract
ObjectiveTo investigate the relationship between white blood cells, neutrophil-lymphocyte ratio(NLR), platelet-lymphocyte ratio(PLR) and monocyte-lymphocyte ratio(MLR) with patients suffering from first episode depression.
MethodsThis retrospective study was conducted among inpatients of Hebei General Hospital from January 2021 to December 2021.Ultimately, 193 patients with first-episode depression were enrolled.According to the score of Hamilton depression scale-24 (HAMD-24), the patients were divided into mild-moderate depression group(20≤HAMD-24<35 score, n=98) and severe depression group (HAMD-24 score ≥35, n=95). White blood cells and the counts of each cell subtype were detected and the NLR, MLR and PLR were calculated.SPSS 25.0 statistical software was used to analyze the data.Mann-Whitney U test was used to compare differences in the two groups and Binary Logistic regression analyses were performed to recognize the predictive factors of the severity of first episode depression.
Results(1) The white blood cells and NLR in the severe depression group were significantly higher than those in the mild-moderate depression group (white blood cells: 5.77(2.05)×109/L vs 5.11(1.31)×109/L; NLR: 1.86 (1.04) vs 1.57(0.55), P<0.05). There were no significant differences in PLR and MLR between the two groups (P>0.05). (2)Multiple regression analysis of NLR, white blood cells and HAMD-24 score showed that there were significant differences in the effect of different white blood cells and NLR levels on HAMD-24 score(B=1.398, P=0.003; B=2.624, P=0.001). (3)Binary Logistic regression revealed that white blood cell count and NLR were risk factors for the severity of depression patients(OR were 1.612 and 2.336, respectively, P<0.05).
ConclusionThe results suggest that white blood cells and NLR may be relate with the severity of first episode depression.
Key words:
Depression; White blood cell count; Neutrophil-lymphocyte ratio; Severity
Contributor Information
Jin Man
Department of Neurology, Hebei General Hospital, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China
Liang Hao
Cardiology Department, Hebei General Hospital, Shijiazhuang 050051, China
Ni Aihua
Department of Neurology, Hebei General Hospital, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China
Zhang Shipan
Department of Neurology, Hebei General Hospital, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China
Fei Di
Department of Neurology, Hebei General Hospital, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China
Lyu Peiyuan
Department of Neurology, Hebei General Hospital, Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang 050051, China
