Review
Research progress and application status quo of DNA methylation in forensic medicine
Song Binghui, Guo Kan, Fu Junjiang
Published 2023-02-15
Cite as Int J Genet, 2023, 46(1): 37-49. DOI: 10.3760/cma.j.cn231536-20221021-00099
Abstract
At present, epigenetics has been intensively studied in various fields, and has a high application and research value in forensic medicine because of its special mode of inheritance that is not predicated on DNA sequence alteration. As the earliest discovered and most studied epigenetic phenomenon in epigenetics, DNA methylation has provided new ideas and methods to solve forensic practice problems such as identification of monozygotic twins, estimation of age, and identification of tissues and body fluids. In this review, we summarize and conclude the common detection methods of DNA methylation in forensic medicine and describe the research progress and application status quo of DNA methylation in the identification of monozygotic twins, estimation of age and identification of tissues and body fluids. In this way, the close links between DNA methylation and forensic medicine are showed, and its research values and application prospects in the field of forensic medicine are discussed.
Key words:
DNA methylation; Forensic medicine; Epigenetics; Identification of monozygotic twins; Estimation of age; Identification of tissues and body fluids
Contributor Information
Song Binghui
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Laboratory of Precision Medicine and DNA Forensic Medicine the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Guo Kan
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Laboratory of Precision Medicine and DNA Forensic Medicine the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Fu Junjiang
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Laboratory of Precision Medicine and DNA Forensic Medicine the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China
Laboratory of Forensic DNA, Judicial Authentication Center, Southwest Medical University, Luzhou 646000, China
