Data Research and Utilization
Discussion on the anti-tumor metastasis mechanism of Notoginseng Radix et Rhizoma based on internet pharmacology
Songjiang Liu, Xinhua Zhao, Dongxu Zhang, Bowen Sui, Yu Li, Lijia Zhang, Yu Liu, Xueying Pang
Published 2023-06-30
Cite as Int J Trad Chin Med, 2023, 45(6): 749-754. DOI: 10.3760/cma.j.cn115398-20200611-00089
Abstract
ObjectiveTo analyze and explore the possible mechanism of anti-tumor metastasis of Notoginseng Radix et Rhizoma using Internet pharmacology.
MethodsThe active components and targets of Notoginseng Radix et Rhizoma were screened by retrieving Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). GeneCards database was used to screen the anti-tumor metastasis-related targets, and compounds and disease targets were under mapping analysis. Key targets of Notoginseng Radix et Rhizoma for anti-tumor metastasis were screened through Venn map. With the help of Cytoscape 3.7.2 software, a compound-disease network diagram was constructed. String platform was used to build a PPI network. Bioconductor was used to enrich the target genes for KEGG signaling pathway and GO biological process analysis.
ResultsTotally 119 active components were selected from Notoginseng Radix et Rhizoma. There were 8 eligible active components, corresponding to 162 related targets, 121 targets related to anti-tumor metastasis, and 30 key targets screened by PPI network, including AKT1, MAPK1, JUN, RELA, IL6, etc. GO enrichment analysis mainly involved biological processes such as cytokine receptor binding, heme binding, RNA polymerase Ⅱ transcription factor binding, ubiquitin protein ligase binding, and steroid hormone receptor activity. 149 signal pathways related to Notoginseng Radix et Rhizoma anti-tumor metastasis were obtained by KEGG enrichment analysis, mainly involving multiple signal pathways, such as AGE-RAGE and PI3K-Akt, and hepatitis B, Kaposi's sarcoma-associated herpes virus infection, human cytomegalovirus infection and other viral infections and various tumors.
ConclusionNotoginseng Radix et Rhizoma can pass multiple active components, such as ginsenoside f2, ginsenoside rh2 β-, sitosterol, stigmasterol and quercetin, and multiple targets, such as AKT1, MAPK1, JUN, RELA and IL6, acting on multiple pathways such as PI3K-Akt, thereby playing the role of anti-tumor metastasis.
Key words:
Notoginseng Radix et Rhizoma (TCD); Network pharmacology; Anti-tumor metastasis; Molecular mechanisms of pharmacological action (TCD)
Contributor Information
Songjiang Liu
Department of Oncology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
Xinhua Zhao
Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150036, China
Dongxu Zhang
Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150036, China
Bowen Sui
Department of Respiratory Medicine, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
Yu Li
Department of Oncology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
Lijia Zhang
Base Office of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
Yu Liu
Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150036, China
Xueying Pang
Department of Oncology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
