To analyze the clinicopathological characteristics in patients with cervical cancer treated with chemoradiotherapy, or post-operational chemoradiotherapy, and to explore the high-risk factors associated with radiation-induced cystitis (RIC). 107 patients with cervical cancer was retrospectively recruited into the study who were treated with chemoradiotherapy alone, post-operational chemoradiotherapy, 42 and 65 patients, respectively. The surgical status, FIGO staging, total and fractionated doses of radiotherapy, and multiparameters including the dose and volume irradiated to the toltal bladder and bladder wall were evaluated for RIC. The combination of surgery and chemoradiotherapy may increase the incidence and severity of radiation-induced cystitis when compared to chemoradiotherapy alone suggesting that the neurogenic bladder caused by surgical injury is the main cause of bladder toxicity.

Cervical cancer; Radiotherapy; Bladder toxicity; Radiation-induced cystitis