Scientific Research
Application of cisatracurium by different administration methods in renal transplantation
Deng Qun, Jiang Jingjing
Published 2023-08-15
Cite as IMHGN, 2023, 29(16): 2277-2280. DOI: 10.3760/cma.j.issn.1007-1245.2023.16.013
Abstract
ObjectiveTo observe the effects of total intravenous anesthesia with cisatracurium in different ways for renal transplantation on the anesthetic amount and the patients' recovery indicators.
MethodsOne hundred and twenty-three patients who took renal transplantation at Zhengzhou Seventh People's Hospital from January 2021 to October 2022 were selected for the randomized controlled trial. They were divided into groups A (62 cases) and B (61 cases) by lottery. There were 30 males and 32 females in group A; they were (62.58±5.33) years old. There were 31 males and 30 females in group B; they were (60.46±5.29) years old. Group A took target-controlled infusion, and group B continuous infusion. The anesthesia, operation, postoperative recovery, and anesthesia safety of the two groups were compared. t and χ2 tests were applied.
ResultsAfter the anesthesia by different administration methods, the onset time of muscle relaxation in group A was shorter than that in group B, and the maintenance time was longer than that in group B (both P<0.05); the maintenance dose of anesthesia in group A was lower than that in group B [(27.22±5.13) mg vs. (30.77±5.48) mg, t=3.710, P<0.001)]. There were no statistical differences in the intraoperative bleeding volume and operation time between the two groups (both P>0.05). The postoperative eye opening time and extubation time in group A were shorter than those in group B [(7.45±2.28) min vs. (8.82±2.36) min and (9.27±2.46) min vs. (10.49±2.39) min; t=3.274 and 2.789; P=0.001 and 0.006)]. The times for the recovery of muscle relaxation (TOF) ≥ 25% and ≥ 75% in group A were shorter than those in group B (both P<0.05). The incidence of anesthesia related complications in group A was lower than that in group B [4.84% (3/62) vs. 14.75% (9/61); χ2=5.558, P=0.018].
ConclusionTarget controlled infusion of cisatracurium has high application value in total intravenous anesthesia for renal transplantation, can shorten the onset time of anesthesia and enhance the muscle relaxation effect, and has positive significance in reducing the amount of drug in maintaining anesthesia, improving the recovery of muscle relaxation, and reducing the risk of anesthesia related complications.
Key words:
Renal transplantation; Ciatracurium; Target controlled infusion; Continuous infusion
Contributor Information
Deng Qun
Department of Anesthesiology, Zhengzhou Seventh People's Hospital, Zhengzhou 450000, China
Jiang Jingjing
Department of Anesthesiology, Zhengzhou Seventh People's Hospital, Zhengzhou 450000, China
