Special Column for Reproductive Genetics
Chromosomal aneuploidy and pregnancy outcomes for D5/D6 blastocysts from patients undergoing PGT-A treatment
Shi Senlin, Shi Qiongyao, Yao Guidong, Liu Yan, Zhang Fuli
Published 2023-09-10
Cite as Chin J Med Genet, 2023, 40(9): 1062-1067. DOI: 10.3760/cma.j.cn511374-20220602-00378
Abstract
ObjectiveTo compare the prevalence of chromosomal aneuploidies and pregnancy outcomes of D5 and D6 blastocysts subjected to preimplantation genetic testing for aneuploidy (PGT-A).
MethodsClinical and laboratory data of 268 couples who underwent PGT-A at the Reproductive Center of the First Affiliated Hospital of Zhengzhou University from September 2018 to September 2020 were collected. The prevalence of chromosomal aneuploidies and pregnancy outcomes of D5/D6 biopsied blastocysts were compared.
ResultsCompared with D6 blastocysts, the euploidy rate of D5 blastocysts was significantly higher (49.1% vs. 41.1%, P=0.001 1), whilst their aneuploidy rate was significantly lower (50.9% vs. 58.9%, P=0.001 1). The rate of numerical abnormalities of D6 blastocysts was significantly higher than that of D5 blastocysts (27.9% vs. 20.2%, P=0.000 5). For patients under 35 years old, the euploidy rate of D5 blastocysts was significantly higher than that of D6 blastocysts (53.8% vs. 44.3%, P=0.001), whilst the numerical abnormality rate was significantly lower (16.3% vs. 23.9%, P=0.001). For both D5 and D6 blastocysts, the euploidy rates for patients ≤ 35 were significantly higher than those for > 35. The elder group had the lowest rates for aneuploidies and live births. Compared with those receiving D6 blastocysts transplantation, the pregnancy rate, implantation rate and live birth rate for those receiving thawed D5 blastocysts transplantation were significantly higher (60.2% vs. 37.0%, P=0.000 3; 59.1% vs. 37.0%, P=0.000 6; 47.7% vs. 28.3%, P=0.002).
ConclusionFor patients undergoing PGT-A, the chromosomal euploidy rate for D5 blastocysts is higher than that for D6 blastocysts, and the clinical outcome of D5 blastocysts with normal signal is better than that of D6 blastocysts. Elder patients have a higher rate of aneuploidies.
Key words:
PGT-A; Chromosomal aneuploidy; D5/D6 blastocyst; Pregnancy outcome
Contributor Information
Shi Senlin
Center of Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Shi Qiongyao
Center of Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Yao Guidong
Center of Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Liu Yan
Center of Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Zhang Fuli
Center of Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
