Review
Research progress in associations between dental caries and systemic diseases
Wang Xinhuan, Xu Ziqi, Bian Zhuan, Meng Liuyan
Published 2024-01-09
Cite as Chin J Stomatol, 2024, 59(1): 99-104. DOI: 10.3760/cma.j.cn112144-20230926-00169
Abstract
Dental caries is a bacteria-mediated, multifactorial, chronic progressive disease that results in the phasic demineralization and remineralization of dental hard tissues. In recent years, amounts of studies have focused on the association between dental caries and systemic diseases. This paper reviews the researches about associations between caries and systemic diseases. An electronic search was conducted in PubMed and Web of Science for articles published from 2003 to 2022 in the English language. Studies were included in the following ten categories of systemic diseases: cardiovascular diseases, metabolic disorders, respiratory diseases, autoimmune rheumatic diseases, neurologic diseases, gastrointestinal diseases, kidney diseases, skin diseases, iron deficiency anaemia and tumors. This review discusses the relationship between dental caries and systemic diseases, as well as the potentially involved mechanisms, providing new ideas for disease prevention, diagnosis, and treatment strategies for dentists and other clinicians.
Key words:
Dental caries; Streptococcus sobrinus; Streptococcus mutans; Systemic diseases; Dental hard tissues; Oral microbiome
Contributor Information
Wang Xinhuan
State Key Laboratory of Oral &
Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &
Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Xu Ziqi
State Key Laboratory of Oral &
Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &
Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Bian Zhuan
State Key Laboratory of Oral &
Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &
Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Meng Liuyan
State Key Laboratory of Oral &
Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &
Hospital of Stomatology, Wuhan University, Wuhan 430079, China