Meta Analysis
Efficacy and safety of probiotics in treatment of patients with mild cognitive impairment and Alzheimer's disease
Wu Yanjiao, Chen Liping, Hou Huaijing, Xu Ziqing, Zhang Lingyun
Published 2024-01-01
Cite as IMHGN, 2024, 30(1): 1-7. DOI: 10.3760/cma.j.issn.1007-1245.2024.01.001
Abstract
ObjectiveTo explore the efficacy and safety of probiotics in the treatment of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
MethodsThe PubMed, Cochrane Library, EMbase, China National Knowledge Infrastructure, Database for Chinese Technical Periodicals, WanFang Data, and China Biology Medicine disc were searched to collect the studies on the efficacy and safety of probiotics in the treatment of patients with MCI and AD from their establishment to November, 2022. Two reviewers independently screened the literatures, extracted the data, and assessed the risk of bias of the included studies. Meta-analysis was performed using the RevMan 5.4.1 software.
ResultsA total of 10 studies involving 716 patients were included. The results of the meta-analysis showed that the Mini-Mental State Examination score of the probiotic group was better than that of the control group (MD=1.23, 95%CI 0.18-2.27, P=0.02). There was no statistical difference in the incidence of adverse reactions between the two groups (OR=0.63, 95%CI 0.25-1.63, P=0.34).
ConclusionProbiotics have positive effectiveness in improving the cognitive function of patients with MCI and AD, with satisfactory safety.
Key words:
Alzheimer's disease; Probiotics; Mild cognitive impairment; Meta-analysis
Contributor Information
Wu Yanjiao
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Anesthesia Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Chen Liping
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Anesthesia Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Hou Huaijing
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Anesthesia Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Xu Ziqing
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Anesthesia Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Zhang Lingyun
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Anesthesia Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
