Objective To compare the diagnostic value of strain ratio measure method and Itoh scoring system,improved 5-scoring system for differentiation breast benign and malignant solid lesions.Methods Two hundred and sixty-nine patients with 377 lesions(278 benign,99 malignant)were included in the study.The lesion were scored with hoh scoring system and improved 5-scoring system respectively.By the strain ratio measure method equipped with the ultrasonic machine,strain ratio of the lesion was calculated,with 3.08 as the cut-off pont.According to pathologic diagnosis,the diagnostic performance of the 3 methods was evaluated with receiver operating characteristic curve(ROC).Results The area under curve(AUC)of strain ratio measure method was 0.965,that of improved 5-scoring system was 0.951,and that of Itoh scoring system 0.907.The diagnostic performance of strain ratio measure method was almost in the same with improved 5-scoring system(P>0.05),better than hoh system(P=0.021).For the lesions scoring 3 and 4 with improved 5-scoring system,strain ratio measure method had higher accuracy than improved 5-scoring system.Conclusions Strain ratio measure method could provide a new,more objective diagnostic standard for ultrasonic elastography.