Objective To compare the therapeutic effects between transpupillary thermotherapy (TTT) and photodynamic therapy (PDT) for circumscribed choroidal hemangioma(CCH).Methods One hundred and fourteen eyes of 114 cases treated by TTT and twenty eyes of 20 cases treated by PDT were enrolled in the study.Fundus fluorescein angiography(FFA) and ultrasonography(B-scan) were used for examination.In TTT,the entire tumor surface was covered by the laser spots resulting in a gray-white reaction and overlapping laser spots were placed for larger tumors.There were 1 ～ 6 laser spots in each treatment.The session for management was 1 ～ 5 times with 1 ～ 3 months interval.The standard photodynamic therapy with the photosensitizer verteporfin was carried out.The intravenous verteporfin was administered 15 minutes before laser irradiation at 689 nm.Tumors less than 3 mm thick were irradiated for 83 seconds; tumors thicker than 3 mm were irradiated for 166 seconds.The interval time was ≥3 months.Results The five factors were compared.(1) The location of tumor.The rate of efficiency of TTT in foveal and para-foveal cases was 91％ (61/67) and 94.3％ (33/35) in around disk.There was no significant difference in effective rate between the two locations (P =0.563).(2) Retinal detachment.The incidence of retinal detachment over the tumor surface was higher in PDT group than TTT group.(3)Tumor thickness.For tumor with thickness≥4 mm,the effect of TTT was better than PDT penetrate tissue.(4) The response of body tissues and tumor to laser power.There were higher degrees of scarring,pigment,proliferation in TTT cases than PDT cases which only had slight pigment changes and sometimes with delayed chorioretinal atrophy.(5)The efficiency and visual aeuity(VA).There was no significant difference in the rate of efficiency and VA improvement between TTT and PDT groups (P =0.40,0.28).Conclusion The two laser are effective for CCH.The CCH in foveal and para-foveal with less exudation should be treated by PDT.The side effects are needed to be concerned in subsequent treatment.TTT is preferred for thicker tumors with much exudation.