Backgroud Propofol is a clinic frequently used intravenous anesthetic.Anesthesiologists highly concerned about its safety and the possibility of propofol anesthesia-induced damage to patients.Objective This paper reviews the studies about the reproductive toxicity of propofol in recent years and summaries all the related experimental methods.Content Animal experiments revealed that propofol could cause neuron damage to the developing brain.In-vitro fertilization,as analgesic or sedative,propofol accumulation could be detected in the follicular fluid.Controversy still exists whether propofol is harmful to the offspring in cesarean section or non-obstetric surgery during pregnancy.Trend Further clinical studies of reproduction toxicity of propofol are urgently needed,as well as proper approaches assessing the toxicity of anesthetics on future generation.