Objective To investigate the clinical and laboratory characteristics and survival of Chinese patients with T-cell prolymphocytic leukemia (T-PLL).Method Eleven patients with T-PLL admitted in our hospital from Jan 2006 to Oct 2012 were retrospectively analyzed.Results Of the 11 patients,nine were males and two females,with the median age of 56.0(19-69) years old.All the patients,except for three,presented with leukocytosis.The incidence of hyperleukocytosis (1/11) was less frequent than that in the British series (75％) (P =0.000).Lymphocyte counts in peripheral blood were increased in 9 of the 11 patients with the median absolute lymphocyte count (ALC) of 17.22 (0.58-148.83)× 109/L.Superficial lymphadenopathy and splenomegaly were the most common physical signs.It was common that serum lactate dehydrogenase (LDH) and beta 2 microglobulin (β2-MG) were higher than normal level.All cases were positive for CD2/CD3/CD5/TCRαβ,negative for CD1a/HLA-DR and TdT,and most of them were strong positive for CD7 expression.By chromosome analyses,most cases (9/10) have normal chromosome.This rate is significantly higher than that of the British and American series (3％ and 25％,respectively) (P =0.000,P =0.001).The 14qll abnormality and trisomy 8q,which are common among Western cases,were not observed in any of our cases.With a median follow-up of 23.0 months,three patients died.Two year progress free survival (PFS) and overall survival (OS) were 53.3％ and 50％,respectively.There were 3 patients with PFS over a number of years,whether it should be considered as the T-chronic lymphocytic leukemia (T-CLL) is worthy of further studies.Conclusion The common clinical manifestations of T-PLL patients were increased lymphocyte counts and lymphadenopathy as well as splenomegaly.And most cases have high level of blood LDH and β2-MG and normal chromosome karyotype.